SEMINARIO DI BIOLOGIA MOLECOLARE : Molecolar basis of ageing

Responsabile didattico: Gianluca Tell

Durata: 28 ore

Periodo didattico: primo semestre



Title: Active Ageing: from molecular basis to impacts on society

Keynote speaker: Prof. Vilhelm A. Bohr                                                                                                                                         

Director, Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD and Danish Center for Healthy Aging, University of Copenhagen, 2200 Copenhagen, Denmark21224, USA.

Speakers: Proff. Gianluca Tell, Sonia Calligaris, Valeria Filì, Davide Anchisi, Alessandro Cavarape, Gianluigi Gigli.

Biological ageing can be thought of as a progressive decline in the function of the cells of an organism, ultimately resulting in senescence. In recent years, there has been a considerable development towards a better understanding of the underlying causes of aging, the hallmarks of aging.  These include genome instability and mitochondrial dysfunction as major elements.  Both of these and others are associated with increased oxidative stress, major component of aging.  It is emerging that macromolecular damage is a major driver of aging, in particular damage to DNA. Major themes of the course will be the potential molecular causes of ageing and the roles that many different factors might have in contributing to cell loss and tissue decline with age.  Aging is the highest risk factor for age-associated diseases such as cancer, cardiovascular disease and neurodegeneration, so to prevent or intervene against these diseases we need to understand the fundamental changes caused by aging.


  • 2 hours. Vilhelm Bohr. Human and population aging. Human Hallmarks of aging and age associated diseases. DNA damage and repair
  • 2 hours. Vilhelm Bohr. Mitochondrial dysfunction and neurodegeneration. Lifestyle changes and interventions to improve healthspan
  • 2 hours. Gianluca Tell. Molecular mechanisms involved in DNA repair and in genomic instability in normal, senescent and cancer cells.
  • 2 hours. Gianluca Tell. Gene expression, ncRNA and the cell senescent phenotype in the ageing process
  • 2 hours. Davide Anchisi. Physiopathology of ageing and effects on learning and behavior
  • 4 hours. Gianluigi Gigli. Clinical, pathological and biological diagnosis of neurodegenerative diseases. Defining boundaries along a continuum
  • 4 hours. Alessandro Cavarape. Fragility in older people: clinical issues and aspects of prevention.
  • 6 hours. Sonia Calligaris. Food for Active Ageing: Base definitions: food, functional foods, food supplements. Overview on food bioactive compounds for healthy ageing. Food design to deliver target functionalities
  • 2 hours. Valeria Filì. Principles and organization of the Italian Healthcare System
  • 2 hours. Valeria Filì. The in/sustainability of the Italian Welfare System


Elenco corsi 2019/2020